
The apoptosis and autophagy both regulate the biological processes that play a central role in network homeostasis, development, and disease. Anti-apoptotic protein, BCL-2, interact with evolutionary autophagy protein, beclin 1. However, a little known about the functional significance of this interaction. Here, we indicate that the antipoptotic protein BCL-2 wild type, but not binding 1 mutant that is damaged from BCL-2, inhibits autophagy 1-dependent in yeast and mammals and that BCL-2-transgenic expression of BCL-2 inhibits autophagy in the heart of the muscle.
Furthermore, Becklin 1 mutant that cannot bind BCL-2 pushes more autophagy than the type of wild Beck 1 and, unlike the type of wild Becker 1, promotes cell death. Thus, BCL-2 not only functions as an antipoptotic protein, but also as an antiautophagy protein through its inhibitory interaction with Becklin 1. This antiautophagy function of BCL-2 can help keep autophagy at a level compatible with cell survival, not death cells.
Identify the specific microrna network from the mouse.
Microrna (MIRNAS) is a new class of RNA not coded, which is encoded as a short reverse repetition in the invertebrate genome and vertebrate. It is believed that MIRNAS is a translation modulator and stability of the target MRNA, although most MRNAS targets remain identified. Here we describe identifying 34 mirnas novels with network-specific cloning around 21-nucleotides RNA from the mouse. Almost all MIRNAs identified are preserved in the human genome and are also often found in nonmamalia vertebrate genomes, such as pufferfish.
In the heart, heart, or brain, it was found that the Mirna expressed specifically the network dominated the MIRNA population expressed and showed the role for MIRNAs in network specifications or cell lineage decisions. Finally, Mirna was identified that seemed to be a fruit orthologist and Mammal C. Elegans Lin-4 Strna.
Micronas modulates the differentiation of hematopoietic lines.
Microrna (MIRNAS) is an abundant class of RNAS 22-nucleotide regulation found in plants and animals. Some MIRNAS plants, Elegans Caenorhabditis, and Drosophila played the role of important gene regulations during development with paired to target Mr.NNAS to determine posttransciptional repression from these messages. We identified three MIRNAs specifically expressed in hematopoietic cells and showed that their expressions were regulated dynamically during early hematopoiesis and commitment of lineage. One of the MIRNAs, MIR-181, especially stated in B-lymphoidal cells from the mouse bone marrow, and its ectopic expression in hematopoietic stem cells causes increased B cell-line cell fraction in both network culture differentiation tests. and adult mice. Our results indicate that Microrna is a component of the molecular circuit that controls the hematopoiesis mouse and suggests that other microrna has a similar regulatory role during other aspects of vertebrate developments.
Dystrophin: Protein products from Locus Dystrophy Muscle Duchenne.
Protein products from Dychenne Duchenne Locus Dystrophy (DMD) and homologous mouse (MDMD) have been identified using polyclonal antibodies directed towards fusion proteins containing two different regions of MDMD CDNA. DMD proteins are proven to be around 400 KD and to represent around 0.002% of the total lurik muscle protein. This protein is also detected in plain muscle (stomach).
Muscle tissue isolated from both boys affected by DMD and MDX mice do not contain DMD proteins detected, indicating that this genetic disorder is homologous. Because MDX mice present there are no clear clinical abnormalities, the identification of the MDX corpse as an animal model for DMD has important implications in connection with the deadly etiology of DMD phenotypes. We have named the dytrophin protein because of identification through the insulation of Duchenne muscle locus dystrophy.
Blood monocy consists of two main subsets with different migration properties.
Peripheral blood monocytes are heterogeneous leukocyte populations circulating. Using the Murine Adoption Transfer System to investigate Homing and Monocyte Differentiation in Vivo, we identify two functional parts of the Murine Blood Monocytes: CCR2 (LO) CR1 (+) which is short-lived (+) which is actively recruited for inflamed tissue and CCR (3) (hi) CCR1 (-) (-) subset (-) which is marked with CX (3) recruitment that depends on the CR1 on noninflamed networks. Both subsets have the potential to distinguish dendritic cells in in vivo.
![]() Human MYC Associated Factor X (MAX) ELISA Kit |
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DLR-MAX-Hu-48T | DL Develop | 48T | EUR 517 |
Description: A sandwich quantitative ELISA assay kit for detection of Human MYC Associated Factor X (MAX) in samples from tissue homogenates or other biological fluids. |
![]() Human MYC Associated Factor X (MAX) ELISA Kit |
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DLR-MAX-Hu-96T | DL Develop | 96T | EUR 673 |
Description: A sandwich quantitative ELISA assay kit for detection of Human MYC Associated Factor X (MAX) in samples from tissue homogenates or other biological fluids. |
![]() Human MYC Associated Factor X (MAX) ELISA Kit |
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RDR-MAX-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 544 |
![]() Human MYC Associated Factor X (MAX) ELISA Kit |
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RDR-MAX-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 756 |
![]() Po (P-Zero) |
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CH23009 | Neuromics | 100 ul | EUR 179 |
![]() T1 Simple Cloning Kit |
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20-abx098056 | Abbexa |
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![]() Blunt Simple Cloning Kit |
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20-abx098060 | Abbexa |
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![]() pUC57 Simple-PVT1 Plasmid |
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PVTB00511 | Lifescience Market | 2 ug | EUR 356 |
![]() pUC57 Simple-Pdcd4 Plasmid |
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PVTB70003 | Lifescience Market | 2 ug | EUR 356 |
![]() pUC57- Simple- gRNA backbone |
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PVT11371 | Lifescience Market | 2 ug | EUR 301 |
![]() Protein Max (MAX) Antibody |
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abx117235-100ug | Abbexa | 100 ug | EUR 467 |
![]() Protein Max (MAX) Antibody |
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20-abx123505 | Abbexa |
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![]() Protein Max (MAX) Antibody |
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20-abx312892 | Abbexa |
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![]() Protein Max (MAX) Antibody |
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20-abx001769 | Abbexa |
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![]() Protein Max (Max) Antibody |
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abx146651-100ug | Abbexa | 100 ug | EUR 439 |
![]() Protein Max (MAX) Antibody |
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abx431420-200ul | Abbexa | 200 ul | EUR 384 |
![]() Protein Max (MAX) Protein |
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20-abx260587 | Abbexa |
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![]() Protein Max (MAX) Antibody |
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abx235033-100ug | Abbexa | 100 ug | EUR 481 |
![]() Giemsa stain |
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GB0477 | Bio Basic | 10g | EUR 60.44 |
![]() Jenner's Stain |
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GT5545-100G | Glentham Life Sciences | 100 g | EUR 160 |
![]() Jenner's Stain |
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GT5545-25G | Glentham Life Sciences | 25 g | EUR 81 |
![]() Giemsa Stain |
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GT6821-100ML | Glentham Life Sciences | 100 ml | EUR 46 |
![]() Giemsa Stain |
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GT6821-250ML | Glentham Life Sciences | 250 ml | EUR 59 |
![]() Wright's stain |
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GT7819-100G | Glentham Life Sciences | 100 g | EUR 110 |
![]() Wright's stain |
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GT7819-10G | Glentham Life Sciences | 10 g | EUR 46 |
![]() Wright's stain |
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GT7819-250G | Glentham Life Sciences | 250 g | EUR 190 |
![]() Wright's stain |
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GT7819-25G | Glentham Life Sciences | 25 g | EUR 58 |
![]() Giemsa stain |
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20-abx082069 | Abbexa |
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![]() Giemsa stain |
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20-abx082518 | Abbexa |
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![]() DiI Stain |
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B2742-250 | Biovision | 250 mg | EUR 753 |
![]() DiI Stain |
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B2742-50 | Biovision | 50 mg | EUR 227 |
![]() Fmoc-Ser(PO(OBzl)OH)-OH |
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B-3455.0001 | Bachem | 1.0g | EUR 297 |
Description: Sum Formula: C25H24NO8P; CAS# [158171-14-3] |
![]() Fmoc-Ser(PO(OBzl)OH)-OH |
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B-3455.0005 | Bachem | 5.0g | EUR 1093 |
Description: Sum Formula: C25H24NO8P; CAS# [158171-14-3] |
![]() Fmoc-Thr(PO(OBzl)OH)-OH |
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B-3460.0001 | Bachem | 1.0g | EUR 321 |
Description: Sum Formula: C26H26NO8P; CAS# [175291-56-2] |
![]() Fmoc-Thr(PO(OBzl)OH)-OH |
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B-3460.0005 | Bachem | 5.0g | EUR 1192 |
Description: Sum Formula: C26H26NO8P; CAS# [175291-56-2] |
![]() Fmoc-Tyr(PO(OBzl)OH)-OH |
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B-3565.0001 | Bachem | 1.0g | EUR 345 |
Description: Sum Formula: C31H28NO8P; CAS# [191348-16-0] |
![]() Fmoc-Tyr(PO(OBzl)OH)-OH |
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B-3565.0005 | Bachem | 5.0g | EUR 1288 |
Description: Sum Formula: C31H28NO8P; CAS# [191348-16-0] |
![]() Fish phenol oxidase (PO) ELISA Kit |
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QY-E160047 | Qayee Biotechnology | 96T | EUR 478 |
![]() Protein Max (MAX) Antibody (HRP) |
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20-abx312893 | Abbexa |
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![]() Protein Max (MAX) Antibody (FITC) |
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20-abx312894 | Abbexa |
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![]() Protein Max (MAX) Antibody (Biotin) |
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20-abx312895 | Abbexa |
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![]() Protein Stain-EZ C, Reversible Copper Stain Kit |
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BSP017 | Bio Basic | 1kit, 10prep | EUR 74.36 |
![]() Protein Stain-EZ B, Reversible Zinc Stain Kit |
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BSP019 | Bio Basic | 1kit, 10prep | EUR 74.36 |
![]() Protein Stain-EZG Rapid Coomassie Blue Stain Solution |
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BSP041 | Bio Basic | 1KIT, 10prep | EUR 76.1 |
![]() 4CN Stain Kit |
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PW024 | Bio Basic | 5Preps, 5prep | EUR 70.88 |
![]() TMB Stain Kit |
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PW025 | Bio Basic | 5Preps, 5prep | EUR 70.88 |
![]() Jenner's Stain, certified |
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GT1148-25G | Glentham Life Sciences | 25 g | EUR 107 |
![]() Giemsa stain, powder |
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GT7801-100G | Glentham Life Sciences | 100 g | EUR 134 |
![]() Giemsa stain, powder |
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GT7801-10G | Glentham Life Sciences | 10 g | EUR 46 |
![]() Giemsa stain, powder |
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GT7801-25G | Glentham Life Sciences | 25 g | EUR 62 |
![]() Giemsa stain, powder |
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GT7801-50G | Glentham Life Sciences | 50 g | EUR 86 |
![]() Giemsa stain, powder |
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GT7801-5G | Glentham Life Sciences | 5 g | EUR 42 |
![]() ClearSight DNA Stain |
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BH40501 | Bioatlas | 1ml | EUR 103 |
Description: For DNA staining and vizualization. |
![]() ClearSight RNA Stain |
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BH40601 | Bioatlas | 400µl | EUR 77 |
Description: For DNA staining and vizualization. |
![]() Silver Stain kit |
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AR0171 | BosterBio | 1 kit (for 30 assays to stain the gel of 5 X8.5) | EUR 152 |
![]() Fite's Stain Kit |
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FLS-1 | ScyTek Laboratories | 125 ml ea. | EUR 149 |
![]() Fite's Stain Kit |
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FLS-500 | ScyTek Laboratories | 500 ml ea. | EUR 295 |
![]() Trichrome Stain (Blue) |
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TGB125 | ScyTek Laboratories | 125 ml | EUR 74 |
![]() Trichrome Stain (Blue) |
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TGB500 | ScyTek Laboratories | 500 ml | EUR 116 |
![]() Trichrome Stain (Blue) |
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TGB999 | ScyTek Laboratories | 1000 ml | EUR 143 |
![]() Pneumocystis Stain Kit |
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PCS-1 | ScyTek Laboratories | 1 kit(s) | EUR 156 |
![]() Pneumocystis Stain Kit |
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PCS-2 | ScyTek Laboratories | 100 Slides | EUR 104 |
![]() Reticulum Stain Kit |
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GRT-1 | ScyTek Laboratories | 1 kit(s) | EUR 255 |
![]() Reticulum Stain Kit |
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GRT-2 | ScyTek Laboratories | 1 kit(s) | EUR 152 |
![]() Gram Stain Kit |
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GSK-1 | ScyTek Laboratories | 125 ml ea. | EUR 125 |
![]() Gram Stain Kit |
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GSK-2 | ScyTek Laboratories | 30 ml ea. | EUR 92 |
![]() Gram Stain Kit |
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GSK-500 | ScyTek Laboratories | 500 ml ea. | EUR 303 |
![]() Iron Stain Kit |
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IRN-1 | ScyTek Laboratories | 1 kit(s) | EUR 149 |
![]() Iron Stain Kit |
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IRN-2 | ScyTek Laboratories | 100 Slides | EUR 101 |
![]() GMS Stain Kit |
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KAA-1 | ScyTek Laboratories | 125 ml ea. | EUR 216 |
![]() GMS Stain Kit |
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KAA-1000 | ScyTek Laboratories | 1000 ml ea. | EUR 884 |
![]() GMS Stain Kit |
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KAA-500 | ScyTek Laboratories | 500 ml ea. | EUR 523 |
![]() Copper Stain Kit |
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CSK-1 | ScyTek Laboratories | 1 kit(s) | EUR 189 |
![]() Copper Stain Kit |
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CSK-2 | ScyTek Laboratories | 1 kit(s) | EUR 120 |
![]() Fite's Stain Kit |
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K1425-125 | Biovision | EUR 370 |
![]() Geimsa Stain Kit |
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K1426-30 | Biovision | EUR 289 |
![]() Geimsa Stain Kit |
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K1426-500 | Biovision | EUR 468 |
![]() GMS Stain Kit |
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K1427-125 | Biovision | EUR 446 |
![]() Gram Stain Kit |
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k1428-125 | Biovision | EUR 392 |
![]() Gram Stain Kit |
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k1428-30 | Biovision | EUR 262 |
![]() Orcein Stain Kit |
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K1432-125 | Biovision | EUR 501 |
![]() Orcein Stain Kit |
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K1432-30 | Biovision | EUR 359 |
![]() Pneumocystis Stain Kit |
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K1434-125 | Biovision | EUR 425 |
![]() Pneumocystis Stain Kit |
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K1434-30 | Biovision | EUR 316 |
![]() Steiner Stain Kit |
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K1435-125 | Biovision | EUR 446 |
![]() Papanicolaou Stain Kit |
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K1440-30 | Biovision | EUR 207 |
![]() Papanicolaou Stain Kit |
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K1440-500 | Biovision | EUR 278 |
![]() Human MAX/ Protein max ELISA Kit |
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E1557Hu | Sunlong | 1 Kit | EUR 571 |
![]() Chicken Protein max (MAX) ELISA Kit |
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abx512851-96tests | Abbexa | 96 tests | EUR 911 |
![]() Mouse Protein max (MAX) ELISA Kit |
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abx512853-96tests | Abbexa | 96 tests | EUR 668 |
![]() Rat Protein max (MAX) ELISA Kit |
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abx512854-96tests | Abbexa | 96 tests | EUR 668 |
![]() Human Protein max (MAX) ELISA Kit |
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abx253842-96tests | Abbexa | 96 tests | EUR 668 |
![]() Human MAX(Protein max) ELISA Kit |
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EH0886 | FN Test | 96T | EUR 567.6 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
![]() MAX Antibody |
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1-CSB-PA010072 | Cusabio |
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Description: A polyclonal antibody against MAX. Recognizes MAX from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
The level of expression of CX (3) CR1 also defines two main human monocyte sets, CD14 (+) CD16 (-) and CD14 (LO) monocytes, which share the potential for phenotypes and homing with the mouse set. These findings raise the potential of new therapeutic strategies in inflammatory diseases.