Anti-Thyroid Peroxidase and Anti-Thyroglobulin Autoantibodies

Synergistic codon optimization and bioreactor cultivation toward enhanced secretion of fungal lignin peroxidase in Pichia pastoris: Enzymatic valorization of technical (industrial) lignins

 

Lignin peroxidase (LiP) is a well-recognized enzyme for its ability to oxidize lignins, but its commercial availability is limited, which hinders the biotechnological application of LiP-based bioprocesses in lignocellulose biorefineries. This study evaluated a combination strategy to improve the expression of LiP to promote its practical use.
The strategy included optimization of the lipH8 gene of Phanerochaete chrysosporium according to the codon usage of Pichia pastoris, followed by fed-batch fermentation using a 14 L bioreactor (10 L working volume). The combination strategy achieved a maximum volumetric LiPH8 activity of 4480 U L-1, protein concentration of 417 mg L-1 and a specific activity of 10.7 U mg-1, which was higher than previous reports. Biochemical characterization showed that the recombinant LiPH8 (rLiPH8) was optimum at pH 3.0, 25 ℃ and 0.4 mM H2O2.
Using the optimized conditions, rLiPH8 was used to treat isolated technical lignins namely soda-anthraquinone (SAQ) lignin and steam explosion (S-E) lignin. High-performance gel permeation chromatography (HP-GPC) analysis showed that the molecular weight (Mw) of SAQ and S-E lignins were increased by 1.43-and 1.14-fold, respectively, after the enzymatic treatment.
Thermogravimetric analysis (TGA) also showed that the thermal stability of the lignins was improved, indicating that the enzyme treatment of lignins with rLiPH8 resulted in lignin re-polymerization. As the first report on rLiPH8 production using P. pastoris, this study has shed light on the possible route for the enhancement of rLiPH8 production and its potential application for upgrading technical lignins.
histofine

histofine

Histidine Tag (His-Tag) Antibody (Biotin)
abx412017-01mg 0.1 mg
EUR 537
  • Shipped within 1 week.

Histidine Tag (His-Tag) Antibody (FITC)
abx412018-01mg 0.1 mg
EUR 495
  • Shipped within 1 week.

Histidine Tag (His-Tag) Antibody (AP)
abx413028-01mg 0.1 mg
EUR 592
  • Shipped within 1 week.

Histidine Tag (His-Tag) Antibody (Biotin)
abx413029-01mg 0.1 mg
EUR 676
  • Shipped within 1 week.

Histidine Tag (His-Tag) Antibody (FITC)
abx413030-01mg 0.1 mg
EUR 592
  • Shipped within 1 week.

Histidine Tag (His-Tag) Antibody (HRP)
abx413033-01mg 0.1 mg
EUR 676
  • Shipped within 1 week.

Hexa Histidine (H6 Tag) Antibody
20-abx130439
  • EUR 356.00
  • EUR 940.00
  • EUR 481.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Hexa Histidine (H6 Tag) Antibody
20-abx132267
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 565.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Penta Histidine Tag (5X His-Tag) Antibody (HRP)
abx415304-125ul 125 ul
EUR 592
  • Shipped within 1 week.

Recombinant Human Fragile Histidine Triad, GST Tag
7-05191 2µg Ask for price

Recombinant Human Fragile Histidine Triad, GST Tag
7-05192 5µg Ask for price

Recombinant Human Fragile Histidine Triad, GST Tag
7-05193 10µg Ask for price

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species)
4-TAX656Ge01
  • EUR 242.00
  • EUR 2430.00
  • EUR 607.00
  • EUR 302.00
  • EUR 211.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species)
4-TAX656Ge22
  • EUR 276.00
  • EUR 2972.00
  • EUR 730.00
  • EUR 352.00
  • EUR 226.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), APC
4-TAX656Ge01-APC
  • EUR 338.00
  • EUR 3167.00
  • EUR 885.00
  • EUR 429.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with APC.

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), Biotinylated
4-TAX656Ge01-Biotin
  • EUR 306.00
  • EUR 2380.00
  • EUR 707.00
  • EUR 373.00
  • EUR 216.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with Biotin.

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), Cy3
4-TAX656Ge01-Cy3
  • EUR 409.00
  • EUR 4181.00
  • EUR 1139.00
  • EUR 530.00
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with Cy3.

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), FITC
4-TAX656Ge01-FITC
  • EUR 290.00
  • EUR 2553.00
  • EUR 728.00
  • EUR 363.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with FITC.

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), HRP
4-TAX656Ge01-HRP
  • EUR 309.00
  • EUR 2761.00
  • EUR 784.00
  • EUR 388.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with HRP.

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), PE
4-TAX656Ge01-PE
  • EUR 290.00
  • EUR 2553.00
  • EUR 728.00
  • EUR 363.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with PE.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), APC
4-TAX656Ge22-APC
  • EUR 389.00
  • EUR 3905.00
  • EUR 1070.00
  • EUR 503.00
  • EUR 238.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with APC.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), Biotinylated
4-TAX656Ge22-Biotin
  • EUR 344.00
  • EUR 2922.00
  • EUR 843.00
  • EUR 427.00
  • EUR 233.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with Biotin.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), Cy3
4-TAX656Ge22-Cy3
  • EUR 477.00
  • EUR 5165.00
  • EUR 1385.00
  • EUR 629.00
  • EUR 276.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with Cy3.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), FITC
4-TAX656Ge22-FITC
  • EUR 331.00
  • EUR 3144.00
  • EUR 876.00
  • EUR 422.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with FITC.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), HRP
4-TAX656Ge22-HRP
  • EUR 354.00
  • EUR 3401.00
  • EUR 944.00
  • EUR 452.00
  • EUR 223.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with HRP.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), PE
4-TAX656Ge22-PE
  • EUR 331.00
  • EUR 3144.00
  • EUR 876.00
  • EUR 422.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with PE.

FHIT Human, Fragile Histidine Triad Human Recombinant Protein, GST Tag
PROTP49789 Regular: 5ug
EUR 479
Description: FHIT Human Recombinant full length protein expressed in E.coli, shows a 43 kDa band on SDS-PAGE. ;The FHIT is fused to GST-Tag and purified by proprietary chromatographic techniques.

Hexa Histidine (H6) Tag Polyclonal Antibody (Pan-species), APC-Cy7
4-TAX656Ge01-APC-Cy7
  • EUR 556.00
  • EUR 6214.00
  • EUR 1651.00
  • EUR 738.00
  • EUR 311.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CPX656Ge21-OVA Conjugated Hexa Histidine (H6)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with APC-Cy7.

Hexa Histidine (H6) Tag Monoclonal Antibody (Pan-species), APC-Cy7
4-TAX656Ge22-APC-Cy7
  • EUR 659.00
  • EUR 7690.00
  • EUR 2020.00
  • EUR 886.00
  • EUR 356.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Pan-species Hexa Histidine (H6) Tag. This antibody is labeled with APC-Cy7.

L-Histidine
20-abx082132
  • EUR 244.00
  • EUR 189.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

L-Histidine
20-abx082338
  • EUR 286.00
  • EUR 203.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

Deamino-histidine
F-3185.0001 1.0g
EUR 273
Description: Sum Formula: C6H8N2O2; CAS# [1074-59-5]

Deamino-histidine
F-3185.0005 5.0g
EUR 756
Description: Sum Formula: C6H8N2O2; CAS# [1074-59-5]

L-Histidine
GM1595-100G 100 g
EUR 78

L-Histidine
GM1595-1KG 1 kg
EUR 285

L-Histidine
GM1595-250G 250 g
EUR 118

L-Histidine
GM1595-25G 25 g
EUR 50

L-Histidine
GM1595-500G 500 g
EUR 181

D-Histidine
GM2039-25G 25 g
EUR 229

D-Histidine
GM2039-5G 5 g
EUR 86

DL-Histidine
GM6216-100G 100 g
EUR 245

DL-Histidine
GM6216-25G 25 g
EUR 110

DL-Histidine
GM6216-5G 5 g
EUR 58

Histidine-tag (poly-His/Hisx6) Protein (His-tag-fusion protein) ELISA Kit, 96 tests, Quantitative
800-440-HIS 1 kit
EUR 895

Histidine Decarboxylase antibody
20R-HR006 50 uL
EUR 918
Description: Rabbit polyclonal Histidine Decarboxylase antibody

L-Histidine, hydrochloride
HB0330 100g
EUR 69.14
  • Product category: Biochemicals/Amino Acids/Derivatives

Human Histidine decarboxylase (HDC)
1-CSB-YP010246HU
  • EUR 586.00
  • EUR 299.00
  • EUR 2172.00
  • EUR 900.00
  • EUR 1442.00
  • EUR 382.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 76.2 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Histidine decarboxylase(HDC) expressed in Yeast

L-Histidine [G-BSA]
DAG3329 1mg
EUR 1222

Histidine Decarboxylase (HDC) Antibody
20-abx004185
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Hexa Histidine (H6) Antibody
20-abx178986
  • EUR 439.00
  • EUR 133.00
  • EUR 1274.00
  • EUR 606.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx212152
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx212209
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx102258
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx128872
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx129910
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Hexa Histidine (H6) Antibody
20-abx131704
  • EUR 342.00
  • EUR 899.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx172821
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug
  • Please enquire.

Histidine Decarboxylase (HDC) Antibody
20-abx327571
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Histidine Decarboxylase (HDC) Antibody
20-abx338469
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Hexa Histidine Protein (OVA)
20-abx651251
  • EUR 258.00
  • EUR 189.00
  • EUR 565.00
  • EUR 286.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

histidine Decarboxylase (HDC) Antibody
abx432798-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

L-Histidine monohydrochloride monohydrate
GM1189-100G 100 g
EUR 70

L-Histidine monohydrochloride monohydrate
GM1189-1KG 1 kg
EUR 269

L-Histidine monohydrochloride monohydrate
GM1189-250G 250 g
EUR 102

L-Histidine monohydrochloride monohydrate
GM1189-25G 25 g
EUR 46

L-Histidine monohydrochloride monohydrate
GM1189-500G 500 g
EUR 158

DL-Histidine monohydrochloride monohydrate
GM7239-100G 100 g
EUR 205

DL-Histidine monohydrochloride monohydrate
GM7239-25G 25 g
EUR 94

DL-Histidine monohydrochloride monohydrate
GM7239-5G 5 g
EUR 46

1-Methyl-L-histidine
HY-W017006 25mg
EUR 153

3-Methyl-L-histidine
HY-W017007 10mM/1mL
EUR 151

Recombinant Histidine Decarboxylase (HDC)
4-RPG476Hu01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P19113
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 27.4kDa
  • Isoelectric Point: 8.5
Description: Recombinant Human Histidine Decarboxylase expressed in: E.coli

Recombinant Histidine Decarboxylase (HDC)
4-RPG476Mu01
  • EUR 501.41
  • EUR 237.00
  • EUR 1605.28
  • EUR 601.76
  • EUR 1103.52
  • EUR 398.00
  • EUR 3863.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P23738
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 32.5kDa
  • Isoelectric Point: 9.7
Description: Recombinant Mouse Histidine Decarboxylase expressed in: E.coli

Recombinant Histidine Decarboxylase (HDC)
4-RPG476Ra01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P16453
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 32.9kDa
  • Isoelectric Point: 9
Description: Recombinant Rat Histidine Decarboxylase expressed in: E.coli

Anti-Histidine Decarboxylase antibody
STJ16101292 50 µl
EUR 990

Anti-Histidine Decarboxylase antibody
STJ16101426 50 µl
EUR 990

L-Histidine, monohydrochloride, monohydrate
HE806 25g
EUR 66.24
  • Product category: Biochemicals/Amino Acids/Derivatives

Tag-100 tag Antibody
abx019172-100ug 100 ug
EUR 356
  • Shipped within 5-10 working days.

Recombinant Human Fragile Histidine Triad
7-05188 5µg Ask for price

Recombinant Human Fragile Histidine Triad
7-05189 25µg Ask for price

Recombinant Human Fragile Histidine Triad
7-05190 1mg Ask for price

Anti-Thyroid Peroxidase and Anti-Thyroglobulin Autoantibodies in the Cerebrospinal Fluid of Patients with Unipolar Depression

 

Introduction: The risk of developing depression is increased in patients with autoimmune thyroiditis. Autoimmune Hashimoto thyroiditis is diagnosed using the serum markers anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibodies.

In rare cases, patients with autoimmune thyroiditis can also suffer from the heterogeneous and ill-defined syndrome of Hashimoto encephalopathy. Biomarkers for Hashimoto encephalopathy or for any brain involvement of autoimmune thyroiditis are currently lacking.

The aim of the present descriptive study was therefore to determine whether a subgroup of seropositive patients shows intrathecal anti-thyroid antibody synthesis in the cerebrospinal fluid (CSF).

Participants and methods: Paired serum and CSF samples from 100 patients with unipolar depression were examined for anti-TPO and anti-TG antibodies using enzyme-linked immunosorbent assays. Antibody-specific indices (ASIs) were calculated for seropositive samples.

These ASIs allow the differentiation between the brain-derived fraction of antibodies and antibodies which are passively diffused from the serum. ASIs >1.4 were assessed as positive for brain-derived antibodies. Additionally, for explorative evaluations, a stricter ASI limit of >2 was applied.

Results: Anti-TPO antibodies were increased in the serum of 16 patients (16%); increased anti-TPO ASIs (>1.4) were detected in 11 of these patients (69%). Anti-TG antibodies in the serum were detected in three patients (3%), with two of them (67%) showing increased ASIs (>1.4).

Overall, the authors found increased anti-thyroid antibodies in 17 of 100 patients (17%), with 13 out of 17 patients showing increased ASIs (76%; range 1.4-4.1). Choosing ASI levels of >2 led to positive findings in six out of 16 patients (38%) with anti-TPO antibodies in their serum but no increase in ASIs in three patients (0%) who were seropositive for anti-TG antibodies.

The patients with elevated ASIs (N = 13) were younger than the ASI-negative patients (N = 87; p = 0.009); no differences were noted in the frequency of CSF, electroencephalography, and/or magnetic resonance imaging alterations.

Discussion: A subgroup of seropositive patients showed intrathecal synthesis of anti-TPO and, more rarely, of anti-TG antibodies, which might be an indication of central autoimmunity in a subgroup of patients with unipolar depression. The confirmation of elevated ASIs as a biomarker for Hashimoto encephalopathy must await further studies. The relevance of the findings is limited by the study’s retrospective and uncontrolled design.

Rabbit Anti-Bird IgM-HRP Conjugate
90521-HRP 100 ul
EUR 347

Goat anti-Cat IgM Antibody
abx401185-1mg 1 mg
EUR 370
  • Shipped within 1 week.

Cat IgM ELISA Kit
E-20M 1 x 96 well plate
EUR 461

Mouse Anti Cat Igm Monoclonal Antibody
DMABT-51977MC 2 ml
EUR 741

Goat Anti Cat Igm Polyclonal Antibody
DPBT-67161GC 1 mg
EUR 580

Goat anti-Cat IgM Antibody (FITC)
abx401186-1mg 1 mg
EUR 467
  • Shipped within 1 week.

Cat IgG (HRP)
65C-CH0203 1 mg
EUR 248
Description: Purified Cat IgG HRP conjugate

Human Catalase (CAT) ELISA Kit
DLR-CAT-Hu-48T 48T
EUR 441
  • Should the Human Catalase (CAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Catalase (CAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Catalase (CAT) ELISA Kit
DLR-CAT-Hu-96T 96T
EUR 570
  • Should the Human Catalase (CAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Catalase (CAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Catalase (CAT) ELISA Kit
DLR-CAT-Mu-48T 48T
EUR 527
  • Should the Mouse Catalase (CAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Catalase (CAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Catalase (CAT) ELISA Kit
DLR-CAT-Mu-96T 96T
EUR 688
  • Should the Mouse Catalase (CAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Catalase (CAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Catalase (CAT) ELISA Kit
DLR-CAT-Ra-48T 48T
EUR 549
  • Should the Rat Catalase (CAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Catalase (CAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Catalase (CAT) ELISA Kit
DLR-CAT-Ra-96T 96T
EUR 718
  • Should the Rat Catalase (CAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Catalase (CAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Catalase (CAT) ELISA Kit
RDR-CAT-Hu-48Tests 48 Tests
EUR 455

Human Catalase (CAT) ELISA Kit
RDR-CAT-Hu-96Tests 96 Tests
EUR 629

Mouse Catalase (CAT) ELISA Kit
RDR-CAT-Mu-48Tests 48 Tests
EUR 557

Mouse Catalase (CAT) ELISA Kit
RDR-CAT-Mu-96Tests 96 Tests
EUR 774

Rat Catalase (CAT) ELISA Kit
RDR-CAT-Ra-48Tests 48 Tests
EUR 583

Rat Catalase (CAT) ELISA Kit
RDR-CAT-Ra-96Tests 96 Tests
EUR 811

Human Catalase (CAT) ELISA Kit
RD-CAT-Hu-48Tests 48 Tests
EUR 436

Human Catalase (CAT) ELISA Kit
RD-CAT-Hu-96Tests 96 Tests
EUR 601

Mouse Catalase (CAT) ELISA Kit
RD-CAT-Mu-48Tests 48 Tests
EUR 533

Mouse Catalase (CAT) ELISA Kit
RD-CAT-Mu-96Tests 96 Tests
EUR 740

Rat Catalase (CAT) ELISA Kit
RD-CAT-Ra-48Tests 48 Tests
EUR 557

Rat Catalase (CAT) ELISA Kit
RD-CAT-Ra-96Tests 96 Tests
EUR 775

Goat Anti Cat Igm Polyclonal Antibody,FITC
DPBT-67159GC 1 mg
EUR 741

Goat anti Cat IgM mu chain
41-GC05 1 mg
EUR 152
Description: Goat anti Cat IgM mu chain secondary antibody

Goat Anti-Cat IgM-Biotin conjugate
71040-BTN 0.5 ml
EUR 225

Goat Anti-Cat IgM-FITC Conjugate
71040-F 0.5 ml
EUR 225

Cat IgG (Fab) (HRP)
65C-CH0212 1 mg
EUR 297
Description: Purified Cat IgG (Fab) HRP conjugate

Rabbit Anti-Cat IgG Antibody (HRP)
20-abx400018
  • EUR 217.00
  • EUR 112.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • Shipped within 5-7 working days.

Goat anti-Cat IgA Antibody (HRP)
abx401189-1mg 1 mg
EUR 439
  • Shipped within 1 week.

Catalase (CAT) Polyclonal Antibody (Human), HRP
4-PAC418Hu01-HRP
  • EUR 277.00
  • EUR 2309.00
  • EUR 671.00
  • EUR 343.00
  • EUR 190.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CAT (Ala401~Glu523)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Catalase (CAT). This antibody is labeled with HRP.

Catalase (CAT) Polyclonal Antibody (Human), HRP
4-PAC418Hu02-HRP
  • EUR 277.00
  • EUR 2309.00
  • EUR 671.00
  • EUR 343.00
  • EUR 190.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Asp10~Asn507 (Accession # P04040)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Catalase (CAT). This antibody is labeled with HRP.

Catalase (CAT) Polyclonal Antibody (Human), HRP
4-PAC418Hu03-HRP
  • EUR 277.00
  • EUR 2309.00
  • EUR 671.00
  • EUR 343.00
  • EUR 190.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CAT (Ser246~Leu366)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Catalase (CAT). This antibody is labeled with HRP.

Catalase (CAT) Monoclonal Antibody (Human), HRP
4-MAC418Hu22-HRP
  • EUR 288.00
  • EUR 2465.00
  • EUR 710.00
  • EUR 359.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser246~Leu366
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Catalase (CAT). This antibody is labeled with HRP.

Catalase (CAT) Monoclonal Antibody (Human), HRP
4-MAC418Hu23-HRP
  • EUR 249.00
  • EUR 1911.00
  • EUR 571.00
  • EUR 303.00
  • EUR 178.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser246~Leu366
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Catalase (CAT). This antibody is labeled with HRP.

GAPDH Antibody - HRP
T0004-HRP 1ml
EUR 920
Description: GAPDH Mouse Monoclonal antibody detects endogenous levels of total GAPDH protein.

Cat IgM ELISA kit 96 tests, Quantitative
300-170-CGM 1 kit
EUR 712

Goat Anti-Cat IgM, aff pure, unlabeled
71040-UL 0.5 mg
EUR 202

Rat IgM (HRP)
65C-CH1215 500 µg
EUR 346
Description: Purified Rat IgM HRP conjugate

HRP-Human IgM
C050106-10ml 10ml
EUR 1790

HRP-Human IgM
C050106-1ml 1ml
EUR 311

Cat IgG (Fab'2) (HRP)
65C-CH0209 1 mg
EUR 291
Description: Purified Cat IgG (Fab'2) HRP conjugate

Goat anti Cat IgG (HRP)
43C-CB0220 2 mg
EUR 368
Description: Goat anti Cat IgG secondary antibody (HRP)

Rabbit anti Cat IgG (HRP)
43C-CB0227 2 mg
EUR 358
Description: Rabbit anti Cat IgG secondary antibody (HRP)

Goat anti Cat IgG (HRP)
43C-CB0234 2 mg
EUR 369
Description: Goat anti Cat IgG secondary antibody (HRP)

Human IgM antibody (Poly-HRP)
61R-I163AHRP40 1 ml
EUR 503
Description: Mouse anti Human IgM secondary antibody (Poly-HRP)

Immunoglobulin M (IgM) Antibody (HRP)
abx139562-01mg 0.1 mg
EUR 439
  • Shipped within 5-12 working days.

beta-Actin Antibody - HRP
T0022-HRP 1ml
EUR 920
Description: beta-Actin Mouse Monoclonal antibody detects endogenous levels of total beta-Actin protein.

Bovine Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-b-48T 48T
EUR 456
  • Should the Bovine Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-b-96T 96T
EUR 590
  • Should the Bovine Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Ch-48T 48T
EUR 426
  • Should the Chicken Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Immunoglobulin M (IgM) in samples from serum, plasma or other biological fluids.

Chicken Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Ch-96T 96T
EUR 549
  • Should the Chicken Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Immunoglobulin M (IgM) in samples from serum, plasma or other biological fluids.

Human Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Hu-48T 48T
EUR 404
  • Should the Human Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Hu-96T 96T
EUR 518
  • Should the Human Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Mu-48T 48T
EUR 411
  • Should the Mouse Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Immunoglobulin M (IgM) in samples from serum, plasma or other biological fluids.

Mouse Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Mu-96T 96T
EUR 528
  • Should the Mouse Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Immunoglobulin M (IgM) in samples from serum, plasma or other biological fluids.

Rat Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Ra-48T 48T
EUR 426
  • Should the Rat Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Immunoglobulin M (IgM) in samples from serum or plasma.

Rat Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Ra-96T 96T
EUR 549
  • Should the Rat Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Immunoglobulin M (IgM) in samples from serum or plasma.

Rabbit Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Rb-48T 48T
EUR 508
  • Should the Rabbit Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Immunoglobulin M (IgM) ELISA Kit
DLR-IgM-Rb-96T 96T
EUR 661
  • Should the Rabbit Immunoglobulin M (IgM) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-b-48Tests 48 Tests
EUR 473

Bovine Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-b-96Tests 96 Tests
EUR 654

Chicken Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Ch-48Tests 48 Tests
EUR 437

Chicken Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Ch-96Tests 96 Tests
EUR 603

Human Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Hu-48Tests 48 Tests
EUR 411

Human Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Hu-96Tests 96 Tests
EUR 565

Mouse Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Mu-48Tests 48 Tests
EUR 419

Mouse Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Mu-96Tests 96 Tests
EUR 578

Rat Immunoglobulin M (IgM) ELISA Kit
RDR-IgM-Ra-48Tests 48 Tests
EUR 437