Extracellular Glutathione Peroxidase GPx3 and Its Function

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Evaluation of Blood-Brain Barrier Integrity Using Vascular Permeability Markers: Evans Blue, Sodium Fluorescein, Albumin-Alexa Fluor Conjugates, and Horseradish Peroxidase

 

The blood-brain barrier (BBB) constituted by endothelial cells of brain microvessels is a dynamic interface, which controls and regulates the transport of various substances including peptides, proteins, ions, vitamins, hormones, and immune cells from the circulation into the brain parenchyma. Certain diseases/disorders such as Alzheimer’s disease, sepsis, and hypertension can lead to varying degrees of BBB disruption.
Moreover, impairment of BBB integrity has been implicated in the pathogenesis of various neurodegenerative diseases like epilepsy. In attempts to explore the wide spectrum of pathophysiologic mechanisms of these diseases/disorders, a variety of experimental insults targeted to the BBB integrity in vitro in cell culture models and in vivo in laboratory animals have been shown to alter BBB permeability causing enhanced transport of certain tracers such as sodium fluorescein, cadaverine-Alexa fluor, horseradish peroxidase, FITC-dextran, albumin-Alexa fluor conjugates, and Evans blue dye across the barrier.
The permeability changes in barrier-type endothelial cells can be assessed by intravascular infusion of exogenous tracers and subsequent detection of the extravasated tracer in the brain tissue, which enable functional and structural analysis of BBB integrity.
In this chapter, we aimed to highlight the current knowledge on the use of four most commonly performed tracers, namely, Evans blue, sodium fluorescein, albumin-Alexa fluor conjugates, and horseradish peroxidase. The experimental methodologies that we use in our laboratory for the detection of these tracers by macroscopy, spectrophotometry, spectrophotofluorometry, confocal laser scanning microscopy, and electron microscopy are also discussed.
Tracing studies at the morphological level are mainly aimed at the identification of the tracers both in the barrier-related cells and brain parenchyma. In addition, BBB permeability to the tracers can be quantified using spectrophotometric and spectrophotofluorometric assays and image analysis by confocal laser scanning microscopy and electron microscopy.
The results of our studies conducted under various experimental settings using the mentioned tracers indicate that barrier-type endothelial cells in brain microvessels orchestrate the paracellular and/or transcellular trafficking of substances across BBB.
These efforts may not only contribute to designing approaches for the management of diseases/disorders associated with BBB breakdown but may also provide new insights for developing novel brain drug delivery strategies.
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Glutathione Peroxidase Activity Colorimetric Assay Kit
K2174-100 100 assays
EUR 516
Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit
K264-100
EUR 642
Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit
K2109-100 100 assays
EUR 641
OxiSelect Total Glutathione (GSSG/GSH) Assay Kit
STA-312 100 assays
EUR 519
Description: The OxiSelect Total Glutathione Assay Kit is a quantitative assay for measuring the total glutathione content within a sample (GSH/GSSG).  Glutathione Reductase reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) in the presence of NADPH.  Subsequently, the  chromogen reacts with the thiol group of GSH to produce a colored compound that absorbs at 405 nm.  The total glutathione content in unknown samples is determined by comparison with the predetermined glutathione standard curve.  The rate of chromophore production is proportional to the concentration of glutathione within the sample.  The rate can be determined from the absorbance change over time.  Metaphosphoric acid is provided to remove interfering proteins or enzymes from samples.
Peroxidase Assay Kit
abx298828-100Assays 100 Assays
EUR 425
  • Shipped within 5-10 working days.
Peroxidase Assay Kit
Z5030052 100 assays
EUR 622
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
Glutathione Peroxidase Assay (GPX), Enzymatic colorimetric assay kit, 96 test, Quantitative
1240-GPX-1 1 kit
EUR 590
Amplite™ Fluorimetric Glutathione Peroxidase Assay Kit *Blue Fluorescence*
11560 200 Tests
EUR 306
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501
OxiSelect Total Glutathione (GSSG/GSH) Assay Kit, Trial Size
STA-312-T 20 assays
EUR 282
Description: The OxiSelect Total Glutathione Assay Kit is a quantitative assay for measuring the total glutathione content within a sample (GSH/GSSG).  Glutathione Reductase reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) in the presence of NADPH.  Subsequently, the  chromogen reacts with the thiol group of GSH to produce a colored compound that absorbs at 405 nm.  The total glutathione content in unknown samples is determined by comparison with the predetermined glutathione standard curve.  The rate of chromophore production is proportional to the concentration of glutathione within the sample.  The rate can be determined from the absorbance change over time.  Metaphosphoric acid is provided to remove interfering proteins or enzymes from samples.
Glutathione Assay Kit
55R-1343 100 assays
EUR 654
Description: Assay Kit for detection of Glutathione in the research laboratory
Glutathione Assay Kit
55R-1354 100 assays
EUR 895
Description: Assay Kit for detection of Glutathione activity in the research laboratory
Glutathione Assay Kit
abx096005-100Assays 100 Assays
EUR 378
  • Shipped within 5-10 working days.
Glutathione Assay Kit
Z5030030 250 assays
EUR 743
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
QuantiChrom Peroxidase Assay Kit
D2PD-100 100
EUR 351
Description: Quantitative determination of peroxidase activity by colorimetric (570nm) or fluorometric (530nm/590nm) methods. Procedure: 20 min. Kit size: 100 tests. Detection limit: 0.8 U/L. Shelf life: 3 months. Shipping: ambient temp; storage: 4, -20°C.
Ascorbate Peroxidase Assay Kit
abx298818-100Assays 100 Assays
EUR 566
  • Shipped within 5-10 working days.
Total Bilirubin Assay Kit
abx098456-Hitachi7020R150ml4R250ml1 Hitachi 7020; R1: 50ml×4 R2: 50ml×1
EUR 222
  • Shipped within 5-12 working days.
Total Bilirubin Assay Kit
abx098456-Hitachi7060R190ml2R245ml1 Hitachi 7060; R1: 90ml×2 R2: 45ml×1
EUR 222
  • Shipped within 5-12 working days.
Total Bilirubin Assay Kit
abx098456-Toshiba120R150ml4R250ml1 Toshiba 120; R1: 50ml×4 R2: 50ml×1
EUR 222
  • Shipped within 5-12 working days.
Total Bilirubin Assay Kit
abx098456-UniversalR160ml2R230ml1 Universal; R1: 60ml×2 R2: 30ml×1
EUR 237
  • Shipped within 5-12 working days.
Total Cholesterol Assay Kit
abx098457-Hitachi7020R150ml4R250ml1 Hitachi 7020; R1: 50ml×4 R2: 50ml×1
EUR 237
  • Shipped within 5-12 working days.
Total Cholesterol Assay Kit
abx098457-Hitachi7060R190ml2R245ml1 Hitachi 7060; R1: 90ml×2 R2: 45ml×1
EUR 222
  • Shipped within 5-12 working days.
Total Cholesterol Assay Kit
abx098457-Hitachi7170R132ml4R28ml4 Hitachi 7170; R1: 32ml×4 R2: 8ml×4
EUR 222
  • Shipped within 5-12 working days.
Total Cholesterol Assay Kit
abx098457-UniversalR160ml2R230ml1 Universal; R1: 60ml×2 R2: 30ml×1
EUR 237
  • Shipped within 5-12 working days.
Total Cholesterol Assay Kit
abx298882-100Assays 100 Assays
EUR 519
  • Shipped within 5-10 working days.
Total Cholesterol Assay Kit
STA-390 192 assays
EUR 508
Description: Cell Biolabs? Total Cholesterol Assay Kits measure the total cholesterol within serum, plasma, cell lysate, or tissue samples. The assays will detect total cholesterol (cholesteryl esters plus free cholesterol) in the presence of cholesterol esterase or only free cholesterol in the absence of the esterase enzyme.
Total Carbohydrate Assay Kit
STA-682 100 assays
EUR 479
Description: The Total Carbohydrate Assay detects total carbohydrates within samples based on the phenol-sulfuric acid method. Total carbohydrate levels in an unknown sample are calculated based on a glucose standard curve. 100 assays/kit.
Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL 96 assays
EUR 572
Glutathione Peroxidase antibody
20C-CR2144SP 1 ml
EUR 221
Description: Sheep polyclonal Glutathione Peroxidase antibody
Glutathione Colorimetric Assay Kit
55R-1351 100 assays
EUR 706
Description: Assay Kit for detection of Glutathione activity in the research laboratory
Glutathione Reductase Assay Kit
55R-1521 200 assays
EUR 706
Description: Assay Kit for detection of Glutathione Reductase in the research laboratory
QuantiChrom Glutathione Assay Kit
DIGT-250 250
EUR 416
Description: Quantitative determination of reduced glutathione by colorimetric (412nm) method. Procedure: 30 min. Kit size: 250 tests. Detection limit: 12 µg/dL (0.4 µM). Shelf life: 12 months. Shipping: ambient temp; storage: 4°C.
Glutathione Reductase Assay Kit
abx298809-100Assays 100 Assays
EUR 378
  • Shipped within 5-10 working days.
Glutathione Colorimetric Assay Kit
K261-100
EUR 512
Glutathione Fluorometric Assay Kit
K251-100
EUR 479
Glutathione Fluorometric Assay Kit
K2098-100 100 assays
EUR 502
Glutathione Colorimetric Assay Kit
K2106-100 100 assays
EUR 529
EnzyChrom Glutahione Peroxidase Assay Kit
EGPX-100 100
EUR 329
Description: Quantitative determination of glutathione peroxidase activity at 340nm. Procedure: 20 min. Kit size: 100 tests. Detection limit: 12 U/L. Shelf life: 3 months. Shipping: on ice; storage: -20°C.
Rat Glutathione peroxidase ELISA kit
E02G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Glutathione peroxidase ELISA kit
E02G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Glutathione peroxidase ELISA kit
E02G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Glutathione peroxidase ELISA kit
E03G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Glutathione peroxidase ELISA kit
E03G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Glutathione peroxidase ELISA kit
E03G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glutathione peroxidase ELISA kit
E04G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glutathione peroxidase ELISA kit
E04G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glutathione peroxidase ELISA kit
E04G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Glutathione peroxidase ELISA kit
E01G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Glutathione peroxidase ELISA kit
E01G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Glutathione peroxidase ELISA kit
E01G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Glutathione peroxidase ELISA kit
E06G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Glutathione peroxidase ELISA kit
E06G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Glutathione peroxidase ELISA kit
E06G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Goat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Glutathione peroxidase ELISA kit
E09G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Monkey Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Glutathione peroxidase ELISA kit
E09G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Monkey Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Glutathione peroxidase ELISA kit
E09G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Glutathione peroxidase ELISA kit
E08G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Glutathione peroxidase ELISA kit
E08G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Glutathione peroxidase ELISA kit
E08G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Glutathione peroxidase ELISA kit
E07G0369-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Glutathione peroxidase ELISA kit
E07G0369-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Glutathione peroxidase ELISA kit
E07G0369-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Total Antioxidant Capacity Assay Kit
55R-1360 100 assays
EUR 689
Description: Assay Kit for detection of Total Antioxidant Capacity in the research laboratory
Total Bile Acids Assay Kit
abx098455-BeckmanR160ml1R220ml1 Beckman; R1: 60ml×1 R2: 20ml×1
EUR 347
  • Shipped within 5-12 working days.
Total Bile Acids Assay Kit
abx098455-Hitachi7020R145ml2R215ml2 Hitachi7020; R1: 45ml×2 R2: 15ml×2
EUR 425
  • Shipped within 5-12 working days.
Total Bile Acids Assay Kit
abx098455-Hitachi7170R121ml1R27ml1 Hitachi 7170; R1: 21ml×1 R2: 7ml×1
EUR 237
  • Shipped within 5-12 working days.
Total Bile Acids Assay Kit
abx098455-Hitachi7170R160ml1R220ml1 Hitachi 7170; R1: 60ml×1 R2: 20ml×1
EUR 347
  • Shipped within 5-12 working days.
Total Antioxidant Capacity Assay Kit
abx298877-100Assays 100 Assays
EUR 425
  • Shipped within 5-10 working days.
Total Carbohydrate Colorimetric Assay Kit
K645-100
EUR 582
Total Sulfite Assay Kit (Colorimetric)
K699-100
EUR 555
Total Collagen Assay Kit (Colorimetric)
K218-100
EUR 620
Total Polyamine Assay Kit (Fluorometric)
K475-100
EUR 572

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer

Mammalian cells possess a multifaceted antioxidant enzyme system, which includes superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione peroxidase systems. The dichotomous role of reactive oxygen species and antioxidant enzymes in tumorigenesis and cancer progression complicates the use of small molecule antioxidants, pro-oxidants, and targeting of antioxidant enzymes as therapeutic approaches for cancer treatment.
It also highlights the need for additional studies to investigate the role and regulation of these antioxidant enzymes in cancer. The focus of this review is on glutathione peroxidase 3 (GPx3), a selenoprotein, and the only extracellular GPx of a family of oxidoreductases that catalyze the detoxification of hydro- and soluble lipid hydroperoxides by reduced glutathione.
In addition to summarizing the biochemical function, regulation, and disease associations of GPx3, we specifically discuss the role and regulation of systemic and tumor cell expressed GPx3 in cancer. From this it is evident that GPx3 has a dichotomous role in different tumor types, acting as both a tumor suppressor and pro-survival protein.
Further studies are needed to examine how loss or gain of GPx3 specifically affects oxidant scavenging and redox signaling in the extracellular tumor microenvironment, and how GPx3 might be targeted for therapeutic intervention.

Hot-Electron-Activated Peroxidase-Mimicking Activity of Ultrathin Pd Nanozymes

 

Light-activated nanozymes can provide a wealth of new opportunities for the chemical industry and biotechnology. However, present remote-controlled catalytic systems are still far from satisfactory.
Herein, we present an interesting example of applying ultrathin Pd nanosheets (Pd NSs) as a light-controllable peroxidase mimic. Since most of Pd atoms are exposed on their surface, Pd NSs with a thickness of 1.1 nm possess high peroxidase-like activity.
More importantly, under light excitation, such intrinsic activity can be further activated by a nearly 2.4- to 3.2-fold. Such a phenomenon can be ascribed to the unique optical property of ultrathin Pd NSs, which can efficiently capture photons to generate hot electrons via surface plasmon resonance effect and thus promote the in situ decomposition of H2O2 into reactive oxygen species radicals (O*).
This enhanced catalysis can also be used for real-time and highly sensitive colorimetric detection of H2O2. We expect our work can provide valuable insights into the rational design of artificial nanozymes with controllable and efficient activity in biomedical diagnostics, drug delivery, and environmental chemistry.

Rubella virus antibody (HRP)
60-RG05 1 ml
EUR 400
Description: Goat polyclonal Rubella virus antibody (HRP) conjugated

Rubella Virus Antibody (HRP)
abx023126-1ml 1 ml
EUR 599
  • Shipped within 5-10 working days.

Influenza A H1N1 Virions Antibody
abx023051-1ml 1 ml
EUR 599
  • Shipped within 5-10 working days.

Influenza A H3N2 Virions Antibody
abx023055-1ml 1 ml
EUR 599
  • Shipped within 5-10 working days.

Influenza B (virions) Antibody (Biotin)
abx023073-1ml 1 ml
EUR 578
  • Shipped within 5-10 working days.

GAPDH Antibody - HRP
T0004-HRP 1ml
EUR 920
Description: GAPDH Mouse Monoclonal antibody detects endogenous levels of total GAPDH protein.

Rubella virus antibody
10R-R119a 1 mg
EUR 370
Description: Mouse monoclonal Antibody raised against Rubella virus

Rubella virus antibody
20-RG04 1 ml
EUR 367
Description: Goat polyclonal Rubella virus antibody

Rubella Virus Antibody
abx023129-1ml 1 ml
EUR 537
  • Shipped within 5-10 working days.

Influenza A H1N1 Virions Antibody (Biotin)
abx023048-1ml 1 ml
EUR 592
  • Shipped within 5-10 working days.

Influenza A H1N1 Virions Antibody (FITC)
abx023050-1ml 1 ml
EUR 648
  • Shipped within 5-10 working days.

Influenza A H3N2 Virions Antibody (Biotin)
abx023053-1ml 1 ml
EUR 578
  • Shipped within 5-10 working days.

Influenza A H3N2 Virions Antibody (FITC)
abx023054-1ml 1 ml
EUR 648
  • Shipped within 5-10 working days.

beta-Actin Antibody - HRP
T0022-HRP 1ml
EUR 920
Description: beta-Actin Mouse Monoclonal antibody detects endogenous levels of total beta-Actin protein.

Goat Anti-Influenza B virions Polyclonal Antibody
DPAB0199 1 ml
EUR 689

Rubella virus antibody (FITC)
60-RG04 1 ml
EUR 367
Description: Goat polyclonal Rubella virus antibody (FITC) conjugated

Rubella Virus Antibody (FITC)
abx023127-1ml 1 ml
EUR 551
  • Shipped within 5-10 working days.

Rubella Virus E1 Antibody
abx022204-1mg 1 mg
EUR 599
  • Shipped within 5-10 working days.

Rubella Virus E1 Antibody
abx022205-1mg 1 mg
EUR 509
  • Shipped within 5-10 working days.

Rubella Virus E1 Antibody
abx022206-1mg 1 mg
EUR 509
  • Shipped within 5-10 working days.

Biotin [HRP]
DAG3197-HRP 1mg
EUR 429

Vitamine B9 [HRP]
DAGDT1440-HRP 1mg
EUR 1105

Vitamine B12 [HRP]
DAGT5413-HRP 1mg
EUR 975

Rubella virus protein
30-1344 1 ml
EUR 381
Description: Purified native Rubella virus protein (Grade III)

Rubella BR2S Antigen
30-1979 1 mg
EUR 1270

Rubella ELISA Kit
55R-RB025G 96 wells
EUR 301
Description: ELISA kit for detection of Rubella in the research laboratory

Rubella Virus Protein
abx670270-1mg 1 mg
EUR 1010
  • Shipped within 1 week.

Rubella Virus Protein
abx670271-1mg 1 mg
EUR 1803
  • Shipped within 1 week.

Rabbit Rubella IgG
QY-E30313 96T
EUR 374

Rubella Virus Capsid Protein Antibody
abx022208-1mg 1 mg
EUR 509
  • Shipped within 5-10 working days.

HRP-IgG Conjugation Kit
55R-HRP 1 mg
EUR 705
Description: HRP conjugation kit for all types of IgG

Recombinant Rubella Virus Rubella Capsid Protein, GST, E.coli-100ug
QP13372-100ug 100ug
EUR 218

Recombinant Rubella Virus Rubella Capsid Protein, GST, E.coli-1mg
QP13372-1mg 1mg
EUR 1061

Recombinant Rubella Virus Rubella Capsid Protein, GST, E.coli-500ug
QP13372-500ug 500ug
EUR 663

Recombinant Rubella Virus Rubella E1 Protein, GST, E.coli-100ug
QP13373-100ug 100ug
EUR 218

Recombinant Rubella Virus Rubella E1 Protein, GST, E.coli-1mg
QP13373-1mg 1mg
EUR 1261

Recombinant Rubella Virus Rubella E1 Protein, GST, E.coli-500ug
QP13373-500ug 500ug
EUR 663

Recombinant Rubella Virus Rubella E2 Protein, Untagged, E.coli-100ug
QP13374-100ug 100ug
EUR 218

Recombinant Rubella Virus Rubella E2 Protein, Untagged, E.coli-1mg
QP13374-1mg 1mg
EUR 1061

Recombinant Rubella Virus Rubella E2 Protein, Untagged, E.coli-500ug
QP13374-500ug 500ug
EUR 663

RV (Rubella Antibody IgG) ELISA test
30 96T/Box Ask for price
  • Area of application: Prepotency testing
Description: ELISA based test for quantitative detection of RV (Rubella Antibody IgG)

RV (Rubella Antibody IgM) ELISA test
31 96T/Box Ask for price
  • Area of application: Prepotency testing
Description: ELISA based test for quantitative detection of RV (Rubella Antibody IgM)

Goat polyclonal antibody for Rubella virus
1701 1 ml
EUR 272.94
Description: This is goat polyclonal antibody against Rubella virus virions for WB, ELISA.

Goat polyclonal antibody for Rubella virus
1703 1 ml
EUR 289.25
Description: This is FITC conjugated goat polyclonal antibody against Rubella virus virions for WB, ELISA.

Goat polyclonal antibody for Rubella virus
1707 1 ml
EUR 289.25
Description: This is Biotin conjugated goat polyclonal antibody against Rubella virus virions for WB, ELISA.

Goat polyclonal antibody for Rubella virus
504 1 ml
EUR 311
Description: This is HRP conjugated goat polyclonal antibody against Rubella virus virions for WB, ELISA.

Mouse Anti Rubella Virus Monoclonal Antibody
DMABT-51535MR 0.2 mg
EUR 663

Goat Anti-Rubella Virion Polyclonal Antibody
DPAB0220 1 ml
EUR 741

Rubella virus E2 protein
30-1281 1 mg
EUR 1321
Description: Purified recombinant Rubella virus E2 protein

Recombinant Rubella Virus E2
7-07861 100µg Ask for price

Recombinant Rubella Virus E2
7-07862 500µg Ask for price

Recombinant Rubella Virus E2
7-07863 1000µg Ask for price

Rubella virus E2 protein
DAGA-498 1mg
EUR 2821

Rubella Virus E1 protein
80-1059 1 mg
EUR 1715
Description: Purified recombinant Rubella Virus E1 protein

Rubella IgM MAX Protein
abx160034-1mg 1 mg
EUR 3502
  • Shipped within 5-10 working days.

Rubella 2-42 Protein
abx069921-1mg 1 mg
EUR 509
  • Shipped within 5-10 working days.

Rubella 2-6 Protein
abx069923-1mg 1 mg
EUR 509
  • Shipped within 5-10 working days.

Rubella Virus Capsid Protein
abx060645-1mg 1 mg
EUR 1817
  • Shipped within 5-10 working days.

Rubella Virus E2 Protein
abx060648-1mg 1 mg
EUR 1713
  • Shipped within 5-10 working days.

Rubella Virus E2 Protein
abx060649-1mg 1 mg
EUR 1428
  • Shipped within 5-10 working days.

Rubella Virus E2 Protein
20-abx260148
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Rubella IgG ELISA Kit
E4666-100
EUR 539

Rubella IgM ELISA Kit
E4667-100
EUR 539

Rubella virus PCR kit
PCR-H481-48R 50T
EUR 524.4
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Rubella virus

Rubella virus PCR kit
PCR-H481-96R 100T
EUR 669.4
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Rubella virus

Rubella Virus E1 Mosaic
PR27125 500 ug
EUR 833

Rubella Virus Capsid C
PR27126 500 ug
EUR 833

Goat Anti-Rat IgG1-HRP Conjugate
50121-HRP 0.5 ml
EUR 225

Goat Anti-Rat IgG2a-HRP Conjugate
50122-HRP 0.5 ml
EUR 225

Goat Anti-Rat IgG2b-HRP Conjugate
50123-HRP 0.5 ml
EUR 225

Goat Anti-Rat IgG2c-HRP Conjugate
50124-HRP 0.5 ml
EUR 225

Monoclonal Anti-Rat IgG1-HRP Conjugate
50126-HRP 0.5 ml
EUR 286

Rabbit Anti-Bird IgM-HRP Conjugate
90521-HRP 100 ul
EUR 347

Concanavalin A Lectin (ConA)-HRP conjugate
CONA15-HRP 0.5 ml
EUR 286

Aleuria Aurantia Lectin (Aal)-HRP conjugate
AAL15-HRP 0.5 ml
EUR 225

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